MERTK Fc Chimera Protein, Human
SKU: 4615550435

MERTK Fc Chimera Protein, Human

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Description

MERTK Fc Chimera Protein, HumanProduct Specification Species Human Synonyms MER, STK Kinase, Tyro12, C Eyk, C Mer, RP38 Accession Q12866 Amino Acid Sequence Ala21 Ile505, with C hIgG1 Fc Expression System HEK293 Molecular Weight 100 150kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4,5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms MER, STK Kinase, Tyro12, C-Eyk, C-Mer, RP38
Accession Q12866
Amino Acid Sequence

Ala21-Ile505, with C-hIgG1 Fc

Expression System HEK293
Molecular Weight

100-150kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4,5% trehalose

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

Graham, D.K. et al. (1994) Cell Growth Differ. 5:647. Graham, D.K. et al. (2006) Clin. Cancer Res. 12:2662.

Background

Tyrosine-protein Kinase Mer, also known as c-Mer and MerTK, is a member of the receptor tyrosine kinase subfamily TAM (Tyro3, Axl, and Mer). Similar to Axl and Tyro3, the extracelluar domain of Mer contains two Ig-like motifs and two fibronectin type III motifs. Mer is not expressed in normal B- and T-cells but expressed in neoplastic B- and T-cell lines . It is also show higher expression in immunosuppressive M2‑like macrophages. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.Mer is known to bind Gas6, Protein S, Tubby, Tubby-like protein 1 (Tulp1), and Galectin-3. Upon binding ligands via the Ig-like motif, Mer is dimerized to trans-autophosphorylate the kinase domain to induce downstream signaling. It has been shown that Mer signaling in macrophages induces M2 polarization, which promote tumor growth, metastasis and evasion of anti-tumor immunity in tumor microenviroment. Inhibition of Mer, especially on leukocytes and macrophages, is an effective anti-cancer therapy

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SKU: 4615550435

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Verified Purchase
Joseph Onkst
Los Angeles, US
★★★★★ 5
Cool toy. Fun for all
Color: Blue
A cool toy. entertainment for the dogs but more so for the dog parents to watch the dogs reaction. Comes with an additional rope just in case, which I loved. Only side note I would say is that the fast mood could be a little faster. My Golden retriever figured out the speed in less than 24 hours and now picks up the toy to try to chew it up, instead of chasing. With him attempting to chew on the toy in the small time I give him, there are no teeth marks yet…this toy appears to be durable. We play in short increments but enjoy the toy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2026
T
Verified Purchase
Tracey SeekMorrison
Lake Worth, US
★★★★★ 3
Fun toy, but not durable for large heavy chewers
Color: Orange, Color: Orange
I bought this for my 80+ pound Goldendoodle, and he absolutely loved it at first. He barked at it, chased it, and it gave him some great exercise and stimulation. It definitely kept his attention and was fun to watch him play with it. Unfortunately, once he was able to get it in his mouth, he chewed the orange end off fairly quickly. The company does include an extra replacement piece, which is actually a great idea and appreciated. However, he ended up chewing that one up too after a few more play sessions. This toy worked well for short-term play and entertainment, but it’s not durable enough for large dogs with strong chewing habits. I think this would be much better suited for small to medium dogs. Great concept, but I would not repurchase for a heavy chewer. Picture of my dog for size reference!! 🫶🐶
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Reviewed in the United States on February 17, 2026
Y
Verified Purchase
YMYZ
Bozeman, US
★★★★★ 5
My Dog Loves It!
Color: Orange
Great interactive toy for my dog! The quality is nice, no weird smell, and it keeps my dog entertained and active for a long time. Worth the price!
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Reviewed in the United States on May 21, 2026
E
Verified Purchase
Elizabeth
Lowell, US
★★★★★ 5
Good quality and definitely worth it for energetic dogs.
Color: Orange
The automatic moving and rolling action really grabs my dog’s attention, and the rope adds extra fun for chasing and playing. It helps reduce boredom and keeps my dog mentally stimulated, especially when indoors. The motion activation works well, and it’s a fun and engaging toy overall.
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Reviewed in the United States on May 3, 2026
L
Verified Purchase
Literally doesn’t work
Carnegie, US
★★★★★ 5
Great Value Toy
Color: Crinkle Duck (Blue), Size: Large, Color: Crinkle Duck (Blue), Size: Large
This toy has been one of my dog’s absolute favorites. He gets excited every time he sees it and will carry it around the house, toss it in the air, and keep himself entertained for a long time. The shape and texture seem perfect for him, and it quickly became one of his go-to toys over everything else in his basket. What I really like is that it holds up reasonably well for the price. It’s definitely not indestructible, and after a lot of play, it will sometimes start to rip—usually around the feet first since that’s where my dog tends to grab and chew the most. But honestly, considering how affordable it is, I don’t mind replacing it when needed. It’s inexpensive enough that rebuying feels worth it because he genuinely loves it that much. I’d rather keep buying a toy he is obsessed with than spend more on something that just sits untouched. It’s fun, cute, and keeps him happy, which is what matters most. Overall, I’d definitely recommend it for dogs who love plush toys and playful chewing.
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Reviewed in the United States on April 28, 2026

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